6th International Meeting on Quadruplex Nucleic Acids, Prague, Czech Republic, May 31st - June 3rd, 2017

Scientific Program

TENTATIVE PROGRAM

Day 1 (Wednesday May 31):

Registration starts from 10:00

13:30 - 13:45   Opening remarks: Lukas Trantirek
13:45 – 14:05 Opening lecture: Jean-Louis Mergny
14:05 - 14:50 Meeting keynote lecture: Martin Gellert "G quartets: the pre-history and its consequences"

SESSION 1 – Quadruplex structure

14:50 – 15:35 Keynote lecture S1-I.: Janez Plavec: Fascinating NMR structures of tetrahelical DNA different from G-quadruplexes
15:35 – 15:55 Danzhou Yang: Promoter G-quadruplexes: structure, function and diversity talk
15:55 – 16:15 talk
16:15 – 16:45 Coffee break
16:45 – 17:05 Jiri Sponer: Structural dynamics and folding of DNA quadruplexes: Theory and experiment.
17:05 – 17:25  talk
17:25 – 17:45 Jonathan B. Chaires: How POT1 unfolds G4 DNA
17:45 – 18:30 Poster flash presentations I
18:30 – 21:00 Poster session I / Poster session compatible Welcome dinner

Day 2 (Thursday June 1)

SESSION 2 – G4 targets/ Quadruplex ligands

9:00 – 9:45 Keynote lecture S1-II.: Anh Tuan Phan: G-quadruplex structure and development G - quadruplex ligands
9:45 – 10:05 Concetta Giancola: Stability of G-quadruplexes and their ligand interactions: a thermodynamic insight.
10:05 – 10:25 talk
10:25 – 10:45  talk
10:45 - 11:15 Coffee break
11:15 – 11:35 Valerie Gabelica: A mass spectrometry insight into G-quadruplex folding and ligand binding
11:35 – 11:55 talk
11:55 – 12:30 Poster flash presentations II
12:30 - 14:00 Lunch

SESSION 2 – G4 biology

14:00 – 14:45 Keynote lecture S2-I.: Stephen Neidle: Where we are with the development of G4 drugs in human cancer
14:45 – 15:05 Marie-Paule Teulade-Fichou: Visualization strategies and molecular tools for probing the G4 genome.
15:05 – 15:25 talk
15:25 – 15:45 talk
15:45 16:15 Coffee break
16:15 – 17:00 Keynote lecture: Naoki Sugimoto: New targets of pharmaceutical drugs; Non-canonical DNA and RNA.
17:00 – 17:20 Xiaogang Qu: Specifically targeting tetraplex nucleic acids
17:20 – 17:40  talk
17:40 – 18:00  Antonio Randazzo: Approaching the interactome of G-quadruplexes
18:00 – 18:20 John Trent: Targeting the human telomere quadruplex system
18:20 21:30  Poster session II Wine and Cheese party

Day 3 (Friday June 2)

SESSION 3 – Quadruplex nanotech / biotech / unusual DNA structures

9:00 – 9:45 Keynote lecture S2-II.: Itamar Willner: Quadruplex Nucleic Acids for Molecular Devices and Functional Materials
9:45 – 10:05  talk
10:05 – 10:25 talk
10:25 – 10:45 Hiroshi Sugiyama: Chemical Biology of G-quadruplex
10:45 – 11:15 Coffee break

 

11:15 – 12.00 Keynote lecture: Dipankar Sen: G4 DNAzymes and ribozymes provide unexpected insights into biology
12.00 – 12.20 talk
12.20 – 12.40 Paula J. Bates : "Antiproliferative G-Quadruplex Oligos: How do they REALLY work?
12:40 – 14:00 Lunch

 

SESSION 4 – G4 biology

14:00 – 14:45 Keynote lecture: Shankar Balasubramanian: Existence and consequences of G-quadruplex structures in DNA.
14:45 – 15:05: Cynthia J. Burrows: Gene Induction Activity of G4s in Promoters
15:05 – 15:25: Nora Calcaterra: G-quadruplexes: non-canonical DNA structures controlling life from the beginning            
15:25 – 15:45 talk
15:45 – 16:15 Coffee break
16:15 – 16.35: Alain Nicolas: Role of G quadruplexes in genome instability
16.35 – 16.55: Tracy Bryan: Implications of G-quadruplexes for human telomere maintenance mechanisms
16:55 – 17:15: Guillaume Guilbaud: G-quadruplex replication and epigenome maintenance
17:15 – 17:35 talk
17:35 – 17:55 talk
17:55 – 18:30 Poster flash presentations III.
18:30 – 20:00 Poster session III. (Wine & Beer)
20:00 – 22:30 Gala dinner

Day 4 (Saturday June 3)

SESSION 4 – G4 biology

9:00 – 9:45 Keynote lecture S2-II.: Nancy Maizels: G-quadruplexes in human health and disease
9:45 – 10:05 Marcel Tijsterman: Dealing with G-quadruplexes that hamper ongoing DNA replication
10:05 – 10:25 talk
10:25 – 10:45 Junjie Guo: The folding landscape of RNA G-quadruplexes in cells
10:45 11:15 Coffee break
11:15 – 11:35 Pavel Ivanov: Diverse biology of RNA G-quadruplexes
11:35 – 11:55 Jean-Pierre Perreault: RNA G-Quadruplexes regulate the biogenesis and function of cancer related microRNAs
11:55 – 12:35 Closing – Awards ceremony

List of speakers

Jean-Louis Mergny

European Institute of Chemistry and Biology, Université de Bordeaux, France

Martin Gellert
Laboratory of Molecular Biology, National Institutes of Health, Maryland, USA

Anh Tuan Phan
Nanyang Technological University, Singapore

Jiri Sponer
Institute of Biophysics, Academy of Sciences of the Czech Republic

Janez Plavec
National Institute of Chemistry, Slovenia

Nancy Maizels
University of Washington, USA

Alain Nicolas
Institut Curie, France

Shankar Balasubramanian
The University of Cambridge, UK

Stephen Neidle
University College London UK

Paula J. Bates
University of Louisville, USA

Naoki Sugimoto
Frontier Institute for Biomolecular Engineering Research (FIBER), Japan

Dipankar Sen
Simon Fraser University, Canada

Concetta Giancola
University of Naples Federico II, Italy

Jonathan B. Chaires
University of Louisville, USA

Cynthia J. Burrows
University of Utah, USA

Hiroshi Sugiyama
Kyoto University, JAPAN

Marie-Paule Teulade-Fichou
Institut Curie, France

Tracy Bryan
University of Sydney, Australia

Xiaogang Qu
Changchun Institute of Applied Chemistry, China

Danzhou Yang
Purdue University, USA

Pavel Ivanov
Brigham and Women's Hospital & Harvard Medical School, USA

Valerie Gabelica
ARNA Laboratory, University of Bordeaux, France

Antonio Randazzo
Universita degli Studi di Napoli “Federico II”, Italy

John Trent
University of Louisville, USA

Itamar Willner
Institute of chemistry, The Hebrew University of Jerusalem, Israel

Nora Calcaterra
Universidad Nacional de Rosario Suipacha, Rosario, Argentina

Guillaume Guilbaud
Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK

Marcel Tijsterman
Leiden University Medical Center, The Netherlands

Junjie Guo
Whitehead Institute for Biomedical Research, Cambridge, UK

Jean-Pierre Perreault
University of Sherbrooke, Canada